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. 2018 Jan 14;14(2):165–177. doi: 10.7150/ijbs.23477

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The karyotype of MEFs and cultured tumor cells derived from xenograft tumors. A. The karyotype of p21^-/-Wrn^-/-+TRF2^ΔBΔM MEFs in their middle stage. The percentage of cell with more than 80 chromosomes increased to 22%. Arrows showed chromosome fusion. B. The karyotype of p21^-/-Wrn^-/-+TRF2^ΔBΔM MEFs in their late stage. The percentage of cell with more than 80 chromosomes increased to 43.9% and double minute chromosomes were observed. Arrows showed chromosome fusion, breakage and double minutes. C. The karyotype of cultured tumor cells derived from a xenograft tumor. Arrows showed chromosome fusion.