Figure 3.
Constitutive activation of β-catenin in MCC accelerated chondrogenesis and osteogenesis in early postnatal development. (A) By using Acan-CreERT2; β-cateninflox(Ex3)/flox(Ex3)mice with Cre activation at P3, we found that Col 2 IHC was more intense in CA-β-cat mice at P7 (arrow). (B-C) High level of Col 1 (B) and DMP1 (C) expression in 7-day CA-β-cat mice indicated the increased osteogenesis in MCC. In addition, there was more accelerated trans-differentiation of chondrocytes into red bone cells in the cartilage region of CA-β-cat mice (arrows).