Table 2.
Statistical analysis results of serum metabolites in LDLR-/-,PSGL-1+/+ and LDLR-/-,PSGL-1-/- mice.
| δ1H (ppm)a | Metabolites | Pathway | 8+8w | 8+12w | 8+16w |
|---|---|---|---|---|---|
| 0.80-0.84 | HDL | Lipid metabolism | ↑** | ↑ | - |
| 0.84 - 0.88(m),1.20-1.30(m) | LDL+VLDL | Lipid metabolism | ↓*** | ↓* | ↓** |
| 1.00,1.03(d) | valine | Amino acid metabolism | ↑* | ↑ | - |
| 1.33(d),4.11(t) | lactate | Carbohydrate metabolism | ↓* | ↓ | ↑* |
| 1.48(d) | alanine | Amino acid metabolism | ↑ | ↑ | ↑ |
| 1.91(s) | acetate | Carbohydrate metabolism | ↑* | - | - |
| 2.14(s) | methionine | Amino acid metabolism | ↑ | ↑ | - |
| 2.12(m),2.44(m) | glutamine | Amino acid metabolism | - | ↑ | ↑* |
| 2.37(s) | pyruvate | Carbohydrate metabolism | ↑** | - | - |
| 2.56, 2.65(dd) | citrate | Carbohydrate metabolism | - | - | ↑* |
| 3.20(s) | choline | Lipid metabolism | ↑*** | ↑** | ↑ |
| 3.22(s), 3.24(s) | PC and GPC | Lipid metabolism | ↑* | ↑** | - |
| 3.43(t) | taurine | Amino acid metabolism | ↑ | ↑ | ↑ |
| 3.57(s) | glycine | Amino acid metabolism | ↑*** | ↑ | ↑ |
Note: a: s denotes singlet, d denotes double, t denotes triple, m denotes multiplet, and dd denotes double doublet. ↑ the increase, ↓ the decrease; * LDLR-/-,PSGL-1-/- mice compared with LDLR-/-,PSGL-1+/+ mice at 8 w, 8+8 w, 8+12 w and 8+16 w. * p<0.05, ** p<0.01, *** p<0.001.