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. 2018 Jan 11;14(1):100–110. doi: 10.7150/ijbs.22555

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Involvement of miR-21 in CAF-cancer cell metabolic coupling and the consequent promotion of tumor progression. A: Mitochondrial fluorescence intensity in cancer cells as observed by fluorescence microscopy. B, C: The expression of SDH and FH was higher in the CAF co-culture group than in the NF and monoculture groups. D, E: The expression of proteins was significantly lower in cancer cells than in CAFs co-cultured with miR-21 inhibitor, suggesting the attenuation of the metabolic coupling phenomenon.