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Involvement of miR-21 in the indirect promotion of pancreatic cancer cell invasion by CAFs. The number of cells passing through was significantly higher in the CAF-CM group than in the phosphate-buffered saline (PBS) or NF-CM induction groups. After transfection with miR-21 inhibitor, the number of cells passing through was significantly lower in the miR-21 inhibitor group than in the CAF-CM induction or blank transfection groups (A, C: Panc-1; B, D: BxPc-3).
