Vascularized xenografts of UACC 903 (A and B) or 1205 Lu (C, D, E, and F) melanoma cells were treated intravenously on alternate days with liposomes containing single agents (Celecoxib 15 mg/Kg or Plumbagin 0.75 or 1.5 mg/Kg body weight), or CelePlum-777 (Celecoxib 15 mg/Kg + Plumbagin 0.75 or 1.5 mg/Kg body weight) for 3 to 4 weeks. The line graph indicates tumor volume (mm3) and inset body weight. Data represent experiments of 3 mice per group, containing two tumors per mouse; bars, S.E.M.