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HPV preferentially and differentially recruits DDR factors to its own genome for productive replication. Under conditions of genotoxic stress, DDR factors are amplified on host DNAs. In the presence of HPV or viral E6 and E7, DDR factors are preferentially recruited to the HPV DNA, leading to DNA lesions and genetic instability in the host genome. This recruitment is amplified in the presence of hydroxyurea treatment.
