Figure 4.

Intercellular KN1 movement through PD requires a post-movement refolding, which could result from ER stress. The non-cell autonomous feature of KN1C (trafficking domain of KN1) protein renders the GFP-GL1-KN1C fusion as a movement protein that moves from mesophyll cell to epidermal cell, whence the GL1 part in the fusion initiates the developmental program for trichome specification. Chaperonin CCT8 is required in the destination cell, in this case the epidermal cell, to refold the post-movement protein. This figure was drawn based on the description by Xu et al. (2011).