Table 1. Summary of published and generated mutants.

Virus	Wild Type	Phenotype
VEEV WT	HLNPGGTCVSIGYGYADRASESIIGAIARQFKF	Wild type
SINV WT	CLNPGGTLVVKSYGYADRNSEDVVTALARKFVR	Wild type
CHIK WT	LLKPGGSLLIRAYGYADRTSERVICVLGRKFRS	Wild type
	Published mutations in nsP2 and Capsid
SINV P726G	CLNGGGTLVVKSYGYADRNSEDVVTALARKFVR	Non-cytopathic in cells (51, 52)
CHIKV P718S	LLKSGGSLLIRAYGYADRTSERVICVLGRKFRS	Does not antagonize macromolecular synthesis shutoff (32)
VEEV Q739L	HLNPGGTCVSIGYGYADRASESIIGAIARLFKF	Non-cytopathic in BHK cells (53)
VEEV CD	Deletion of Amino acids 64-68 in Capsid	No transcription shutoff (54)
	Generated mutations in nsP2 and Capsid
VEEV CD	Deletion of Amino acids 64-68 in Capsid	No transcription shutoff (54)
VEEV CD/739L	Deletion in capsid + nsP2 739L	Unknown
VEEV P713G	HLNGGGTCVSIGYGYADRASESIIGAIARQFKF	Unknown
VEEV P713S	HLNSGGTCVSIGYGYADRASESIIGAIARQFKF	Unknown
VEEV Q739L	HLNPGGTCVSIGYGYADRASESIIGAIARLFKF	Non-cytopathic in BHK cells (53)

Bold red letters indicate mutated amino acid residues.