Table 2. Summary of VEEV mutant phenotypes at early and late times p.i.

		Early times p.i. (6h)				Late times p.i. (18-24h)
		No IFN		Priming		No IFN		Priming
Virus	Replication efficiency	Macromolecular synthesis shutoff	IFN induction	Resistance to anti- viral state	Replication efficiency	Macromolecular synthesis shutoff	IFN induction	Resistance to anti- viral state
WT	+++	+++	None	+	+++	+++	None	+++
nsP2 713G	+++	+++	None	+	+++	+++	None	+++
nsP2 713S	+++	+++	None	+	+++	+++	None	+++
nsP2 739L	+	+	None	+	+++	+++	None	++
CD	+++	+	High	+	+++	+	High	+++
CD/739L	+	+	High	+	++	+	High	++