Fig. 11.

The Emx-htt^KO mice do not show weight loss compared to control mice over their lifespan (A), but do show a mild rotarod defect over their lifespan (B). Seventeen control mice (13 males, 4 females) and 11 Emx-htt^KO mice (8 males, 3 females) were studied for weight, in some cases at different points during the lifespan of individual mice, yielding 19 WT and 12 Emx-htt^KO measured time points. In the case of rotarod, seventeen control mice (13 males, 4 females) and 11 Emx-htt^KO mice (8 males, 3 females) were studied, in some cases at different points during the lifespan of individual mice, yielding 23 WT and 14 Emx-htt^KO measured time points. Overall means for control and Emx-htt^KO mice, irrespective of age, were compared by unpaired two-tailed t-test, while age-related trends were assessed by regression analysis and ANCOVA.