Fig. 12.

The Emx-htt^KO mice are hyperactive in open field, especially under 1 year of age, as revealed by their increased distance traveled (A), increased progression segment length (B), increased speed (C), increased endurance (D), and decreased number of stops (E). The increase in progression segment length was so great that the Emx-htt^KO mice actually performed significantly fewer progression segments (F) than did control mice. Seventeen control mice (13 males, 4 females) and 11 Emx-htt^KO mice (8 males, 3 females) were studied for open field analysis, in some cases at different points during the lifespan of individual mice, yielding 23 WT and 14 Emx-htt^KO measured time points. Control and Emx-htt^KO mice means were compared by unpaired two-tailed t-test, while age-related trends were assessed by regression analysis and ANCOVA.