Table 2.

comparing major findings of the current study and other studies involving conditional deletion of huntingtin in mice.

	Current study	Dragatsis et al., 2000	Dragatsis et al., 2000	Wang et al., 2016	Wang et al., 2016	Pla et al., 2013	Dietrich et al., 2017
Construct driving KO	emx1-driven cre	CAMK2a-driven cre	CAMK2a-driven cre	Nestin-driven CreER	CAAGG-driven CreER	CAMK2a-driven CreER	CAAGG-driven CreER
Selective for Hdh	Cortical pyramidal neurons	Forebrain neurons	Forebrain neurons	Neurons	Global	Forebrain neurons	Global
Deletion onset	E10.5	PND5	E15	2, 4, or 8 months	2, 4, or 8 months	2 month	3, 6, or 9 months
Behavioral phenotype	Motor hyperactivity	Clasping by PND60, hypoactivity by 10–12 months of age	Clasping by PND21, hypoactivity by 10–12 months of age	No motor abnormalities up to 6 months post	No motor abnormalities up to 10 months post	No motor deficit up to 6 months post	Progressive rotarod impairment by 1 month post, clasping and tremors by 6 months post
Overall neuropathology	Smaller cortex and striatum by 3 months of age	Smaller brain	Smaller brain, temporal lobe degeneration by 4–6 months of age	None up to 3 months post	None up to 3 months post	Defective hippocampal neurogenesis	Progressive brain atrophy and thalamic calcification
Cortex neuropathology	Early and nonprogressive reduction in neuron abundance	Gliosis	Neuronal apoptosis at 10 months of age, gliosis	Not examined in detail	Not examined in detail	Not examined in detail	No overt neuronal loss at 14 months post
Striatum neuropathology	Early and nonprogressive reduction in neuron abundance	Gliosis	Neuronal apoptosis at 10 months of age, gliosis	Not examined in detail	Not examined in detail	Not examined in detail	Gliosis but no overt neuronal loss at 12 months post