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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Glia. 2017 Oct 27;66(2):379–395. doi: 10.1002/glia.23251

Figure 6. USP14 inhibitors IU1 and IU1-47 increase protein degradation in S63del L nerves.

Figure 6

(A) The USP14 inhibitor IU1 increased the degradation rate of long-lived proteins in S63del L nerves at a similar concentration (200 μM) used in previous publications (Homma et al. 2015; Lee et al. 2010). The rate of degradation was calculated as in Figure 2. The mean rate of proteolysis for three individual mice was graphed.

(B) IU1 and IU1-47 increased the degradation rate of long-lived proteins in S63del L nerves at a concentration of 2 μM. The rate of long-lived protein degradation was measured as in Figure 2. Error bars represent SEM between mice. A Student’s t-test was performed between IU1 treated and untreated conditions of the same genotype.