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. 2018 Feb 8;3(3):e95396. doi: 10.1172/jci.insight.95396

Figure 3. Swiprosin-1 deletion aggravates kidney injuries in LPS- and CLP-induced sepsis.

Figure 3

(A and B) H&E-stained sections and injury scores of the kidney after i.p. LPS for 6 hours (n = 6, scale bar: 200 μm, *P < 0.05, WT-CON vs. WT-LPS; ###P < 0.001, KO-CON vs. KO-LPS; ┼┼┼P < 0.001, WT-LPS vs. KO-LPS), 1-way ANOVA (LSD test); the results are depicted as the mean ± SEM. (C) Concentrations of the blood urea nitrogen (BUN) and creatinine (Cr) after i.p. LPS for 6 hours (n = 5–7, *P < 0.05, ***P < 0.001, WT-CON vs. WT-LPS; ###P < 0.001, KO-CON vs. KO-LPS; ┼P < 0.05, ┼┼P < 0.01, WT-LPS vs. KO-LPS), 1-way ANOVA (LSD test); the results are depicted as the mean ± SEM. (D and E) H&E-stained sections and injury scores of the kidneys after CLP treatment for 18 hours (n = 6, scale bar: 200 μm, ***P < 0.05, WT-Sham vs. WT-CLP; ###P < 0.001, KO-Sham vs. KO-CLP; ┼┼P < 0.01, WT-CLP vs. KO-CLP), 1-way ANOVA (LSD test); the results are depicted as the mean ± SEM. (F) Concentrations of the blood urea nitrogen (BUN) and creatinine (Cr) after CLP treatment for 18 hours (n = 4–5, *P < 0.05, WT-Sham vs. WT-CLP; **P < 0.01, WT-Sham vs. WT-CLP; ##P < 0.01, KO-Sham vs. KO-CLP; ###P < 0.001 KO-Sham vs. KO-CLP; ┼P < 0.05, WT-CLP vs. KO-CLP), 1-way ANOVA (LSD test); the results are depicted as the mean ± SEM. (G) IL-1β, IL-6, and TNF-α concentrations of the kidney homogenates after i.p. LPS for 6 hours (n = 8, ***P < 0.001, WT-CON vs. WT-LPS; ###P < 0.001, KO-CON vs. KO-LPS; ┼┼P < 0.01, ┼┼┼P < 0.001, WT-LPS vs. KO-LPS), 1-way ANOVA (LSD test); the results are depicted as the mean ± SEM.