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. 2018 Feb 8;3(3):e95396. doi: 10.1172/jci.insight.95396

Figure 6. Swiprosin-1 deficiency attenuates the expression of IFN-γR in LPS-treated peritoneal macrophages.

Figure 6

(A) Activation of the JAK/STAT pathway after IFN-γ treatment for 12 hours (n = 3, *P < 0.05, **P < 0.01, ***P < 0.001 WT-treatment vs. WT-CON; ##P < 0.01, ###P < 0.001, KO-treatment vs. KO-CON; ┼┼P < 0.01, ┼┼┼P < 0.001, WT vs. KO with same treatment), 1-way ANOVA (LSD test); the results are depicted as the mean ± SEM. (B) The expression of IFN-γR in macrophages after LPS treatment for 12 hours (n = 3, ***P < 0.001 WT-LPS vs. WT-0 hour; #P < 0.05, ##P < 0.01, ###P < 0.001, KO-LPS vs. KO-0 hour; ┼┼┼P < 0.001, WT-LPS vs. KO-LPS at the same time point), 1-way ANOVA (LSD test); the results are depicted as the mean ± SEM. (C) Interaction between swiprosin-1 and IFN-γRα in the macrophages after LPS treatment.