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. 2018 Feb 8;3(3):e95417. doi: 10.1172/jci.insight.95417

Figure 7. The CX3CR1-M280/M280 mutation does not impair innate immune effector functions of CD14+ monocytes.

Figure 7

(A) Monocytes from CX3CR1-WT/WT and CX3CR1-M280/M280 donors exhibit similar ability to inactivate opsonized yeast (left panel) and hyphal forms (right panel) of Candida albicans ex vivo, assessed using the alamarBlue cell viability assay. n = 6–8. (B) Monocytes from CX3CR1-WT/WT, CX3CR1-WT/M280, and CX3CR1-M280/M280 donors exhibit a similar ability to produce IL-1β, IL-6, TNF-α, and IFN-γ following Candida albicans stimulation ex vivo, assessed by a Luminex-array assay. Statistical analysis was performed using Mann-Whitney test or unpaired t test, where appropriate (A), or Kruskal-Wallis with Dunn’s multiple comparisons test or 1-way ANOVA with Tukey’s multiple comparisons test, where appropriate (B). n = 10–16. Data represent the mean ± SEM.