Figure 4. Anti-CD122 treatment alters immune compartment in pancreatic islets.

(A) Representative FACS plots of immune cell profiles in pancreatic islets of NOD mice treated with control mAb or ChMBC7 for 7 weeks (from 3–10 weeks of age). (B) Statistical data of the percentages and numbers of indicated subsets from pancreatic islets of the mice treated in A (n = 7 in each group). (C) Representative FACS plots (upper) and statistics (lower) of CD8 subsets from mice as in A (n = 7). (D) Eight-week-old NOD/BDC2.5 mice were treated with control mAb or ChMBC7 for 2 weeks. Representative FACS plots (left) and statistics (right) of CD44⁺CD122^hi subset within pancreatic CD8⁺ T cells (n = 3 in each group). (E) Representative FACS plots (left) and statistics (right) of Tregs from pancreatic islets of mice as in A. (F) The ratios between Tregs and pathogenic cells as indicated from mice as in A. Statistical data are mean ± SEM. Data are representative of 3 independent experiments. P values are calculated using Student’s t test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.