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. 2018 Feb 8;3(3):e97843. doi: 10.1172/jci.insight.97843

Figure 4. Genes differentially expressed in NOD APCs correlate with IL-1–dependent gene signatures from new-onset human T1D.

Figure 4

GSEA for NOD DE genes with 2 human data sets. (A) Enrichment results from Chen et al. (41) showing genes DE lower (n = 282) or higher (n = 175) in patients with recent-onset type 1 diabetes positively correlate with DE genes from NOD APCs. (B) Enrichment results from Cabrera et al. (21) showing that genes expressed at lower (n = 368) or higher levels (n = 160) with IL-1R antagonist treatment of individuals with new-onset T1D negatively correlate with DE genes from NOD APCs. NES, normalized enrichment statistic. Nominal estimated P values determined using GSEA software.