Figure 7. Administration of dipeptide compound LasB inhibitor after infection reduces lung bacterial burden and inflammatory cytokines in Thbs1^–/– mice.

WT mice and Thbs1^–/– mice were inoculated with Pseudomonas aeruginosa strain PA14 (10⁶ CFU inoculum). At 2 hours after infection, mice were administered either vehicle (DMSO) or LasB inhibitor (LasBI) at 200 μg/mouse by i.p. injection. Outcome measurements were obtained 20 hours after infection. (A) Lung CFU/ml, (B) G-CSF, (C) GM-CSF, (D) keratinocyte chemoattractant (KC), (E) IL-6, (F) IL-10, (G) IL-17A, and (H) TNF-α concentrations were measured in lung tissue homogenates. Each data point represents an individual mouse, n = 5 mice per group. Lines indicate the median. *P < 0.05, **P < 0.01 by Kruskal-Wallis test with Dunn’s multiple comparisons.