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. 2018 Feb 8;3(3):e89624. doi: 10.1172/jci.insight.89624

Figure 1. Osteoblast-targeted Ext1 ablation induces osteopenia.

Figure 1

(A) X-ray images of the whole body, femur, and lumbar spine of a 12-week-old Oc-Cre;Ext1flox/flox mouse and a WT littermate. Whole-body images show that there are no gross skeletal abnormalities in Oc-Cre;Ext1flox/flox mice. Images of the femur and lumbar spine show that bones of Oc-Cre;Ext1flox/flox mice are more translucent that those of WT mice. (B) Von Kossa staining of lumbar vertebrae at 5 weeks, 3 months, and 6 months of age. (C) Histomorphometric analysis of bone mass in lumbar vertebrae at 5 weeks, 3 months, and 6 months of age. Data represent the mean ± SD of 5 mice per genotype. CKO, Oc-Cre;Ext1flox/flox; BV/TV, bone volume over tissue volume; Tb.N, trabecular number; Tb.Sp, trabecular separation. ***P < 0.001 by Student’s t test. Scale bar: 5 mm (A, whole body images); 1 mm (A, femur and lumber spine images); 1 mm (B).