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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Clin Pharmacol Ther. 2017 May 26;102(3):511–519. doi: 10.1002/cpt.644

Figure 2. Comparison of mucositis grade versus melphalan AUC and ex vivo log (IC50).

Figure 2

Panel a) shows the relationship between melphalan AUC (N=118), and panel b) shows the relationship between log IC50 (N=115) relative to mucositis grade. The association between AUC or log IC50 values and worst mucositis grade (0 & 1 vs 2 & 3) was analyzed using Wilcoxon rank sum test with continuity correction (two-sided). The numbers of patients with worst mucositis grade 0, 1, 2, 3 were 44, 54, 16, and 4, respectively for the AUC evaluation (N=118 total). The numbers of patients with worst mucositis grade 0, 1, 2, 3 were 43, 52, 16, and 4, respectively for the log IC50 evaluation (N=115 total).