Table 5. Covariates included into the final models.
| P-value | Covariate | Affected parameter | Change of parameter |
|---|---|---|---|
| EGCG final model | |||
| 0.00721 | MRP2_rs717620 | F | CC: -26% |
| 0.01212 | OATP1B1_rs4149056 | CL/F | TT: -0%, CT: -15%, CC: -30% |
| EGC final model | |||
| 0.00001 | Contraceptives | Vcentral/F | -55% |
| 0.00153 | MRP2_rs3740066 | Q/F | CC: +133% |
| 0.00163 | OATP1B1_rs2306283 | CL/F | AA: -35% |
| 0.01654 | MRP2_rs717620 | Vcentral/F | CC: -0%, CT: -37%, TT: -74% |
| 0.01795 | UGT1A1*28 | CL/F | (-): -26% |
| 0.02350 | COMT_rs4680 | F | AA: -24% |
CL: clearance from central compartment, F: relative bioavailability, ka: absorption time constant, Lag time: delay in absorption, Q: intercompartmental clearance, V: volume of distribution. Transporter and enzyme covariates were included into the final model if p≤0.025 during backward elimination