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. 2018 Jan 23;5(2):e1409864. doi: 10.1080/23723556.2017.1409864

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© 2018 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Cutaneous melanoma initiation from melanocyte stem cells is related to adult stem cell status. (a) Quiescent melanocyte stem cells (MCSCs) are refractory to oncogenic expression. However, (b) exposure to ultraviolet-B (UVB) in the environment can induce MCSC activation and migration (MCSC mig.), which in turn causes early melanoma formation throughout the epidermis. Following expansion within the epidermis, the tumor then grows invasively into the dermis (Melanoma growth). (c) Schematic of the role of extrinsic stimuli in melanoma initiation from tumor-prone, quiescent MCSCs.