Table 3.

Evaluation of Allene Scope.^a

^aYields indicate isolated yield of product as a mixture of two diastereomers on a 0.5 mmol scale, unless otherwise indicated. 1.2 equiv of allene was used, see Supporting Information for further details. Diastereomeric ratios determined by ¹H NMR spectroscopy of the crude mixture, using 1,1,2,2-tetrachloroethane as internal standard. Enantiomeric excesses determined by HPLC or SFC analysis on commercial chiral columns; enantiomeric ratios of minor diastereomers indicated in parentheses. Yields, diastereomeric ratios, and enantiomeric excesses are the averages for two identical runs.

^bThe reaction was conducted on a 0.1 mmol scale.