Skip to main content
. Author manuscript; available in PMC: 2018 Feb 21.
Published in final edited form as: J Biopharm Stat. 2015;25(4):757–780. doi: 10.1080/10543406.2014.920871

Figure 3.

Figure 3

Figure 3

Illustration of five situations producing a compound effect size E > 0 (A–E), and three producing E = 0 (F–H) (continued). In A through E, the area of the region highlighted with vertical lines is equal to E. Referring to formulas (11)(13), plot (A) corresponds to the case a > 0, b* > Tmin and max {log (D1),(Tminb)/a}=(Tminb)/a; in plot (B), a > 0, b* > Tmin, but max {log (D1),(Tminb)/a}=log (D1); (C) a = 0, yielding E > 0 because b* > Tmin; (D) a < 0, a log (D1)+b>Tmin and min {(Tminb*)/a, 0} = 0; (E) a < 0, a log (D1)+b>Tmin and min {(Tminb*)/ a, 0} = (Tminb*)/ a ; (F) a = 0, yielding E = 0 because b* < Tmin ; (G) a > 0, b* < Tmin; (H) a < 0 and a log (D1)+b<Tmin.