Fig 3. SEM hypothesis 2.

Positive family history of obesity was the mayor determinant of acylcarnitines and amino acids, This were associated with NAFLD, obesity, insulin resistance and pro-inflammatory process. In this model we proposed obesity as a secondary, or a consequence of a previous alteration of fatty acid and amino acids metabolism. Circles = latent variables, rectangles = observed variables, e = error term. Family History of obesity is formed by: IndFOB = Second degree family history of obesity. DadFHOB = Parental history of obesity. MomFHOB = Maternal family history of Obesity. Latent variable obesity is formed by: BMI = Body mass Index, Abd_circumf = abdominal circumference, FAT = % of Fat. AA1 and AA2 = latent variables that represent factor for amino acids AC1, AC2, AC3 and AC4 = latent variables that represent factors grouped for acylcarnitines. C:0,C2-C18:2. ALA = alanine, CIT = citrulline, Met = methionine, TYR = tyrosine, ORN = ornithine, PRO = proline, ARG = arginine, GLY = glycine, LEU = leucine, PHE = phenylalanine, VAL = valine. CRP = C reactive protein. TNFα = Tumor necrosis factor alpha, IL-6 = Interleukine-6, both form latent variable INFL = inflammatory markers. Latent variable NAFLD integrates USG = liver ultrasound. ALT = Alanine aminotransferase, AST = Aspartate aminotransferase,. Lines in bold correspond to standardized β estimates > 0.2. Numbers in each line corresponds to standardized β estimate Lines in bold correspond to standarized B estimates > 0.2. Numbers in line correspond to standardized β estimates. To simplify, error terms were not included in the figure.