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. 2018 Feb 23;46(3):375–383. doi: 10.1097/CCM.0000000000002847

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Biomarker kinetics in association with specific exposures. Time course of urinary tissue inhibition of metalloproteinase [TIMP-2]•insulin-like growth factor binding protein [IGFBP7] concentrations relative to the time or day of exposure by acute kidney injury (AKI) stage for patients exposed to major surgery (A), IV contrast (B), vancomycin (C), NSAIDs (D), or piperacillin/tazobactam (E). Symbols show median urinary [TIMP-2]•[IGFBP7] concentrations for patients who had no AKI (circles), AKI stage 1 (squares), and AKI stage 2–3 (triangles) within 3 days postexposure. Vertical and horizontal lines through the symbols show the interquartile range of bootstrap medians for the [TIMP-2]•[IGFBP7] concentrations and the time from exposure, respectively. Median urinary [TIMP-2]•[IGFBP7] concentrations are shown by day for drug exposures because only the day and not the time of exposure was recorded. The width of the shaded area indicates the day of the first dose of each drug.