Table 1.
Neuroimaging, demographic and clinical features by cluster
| ELo/CLo (n=21) |
ELo/CHi (n=21) |
EHi/CHi (n=20) |
P | |
|---|---|---|---|---|
|
| ||||
| Neuroimaging features | ||||
| Entorhinal SUVRs | 1.60 [1.48, 1.78] | 1.55 [1.48, 1.63] | 1.95 [1.85, 2.03] | <0.001* |
| Cortical SUVRs | 1.41 [1.32, 1.48] | 1.88 [1.78, 2.19] | 2.12 [2.04, 2.49] | <0.001† |
| Entorhinal/Cortical SUVRs | 1.13 [1.02, 1.23] | 0.79 [0.68, 0.91] | 0.87 [0.81, 1.00] | <0.001‡ |
| Entorhinal gray matter volume (%TIV) | 0.21 [0.16, 0.22] | 0.23 [0.18, 0.25] | 0.20 [0.19, 0.24] | 0.29 |
| Cortical gray matter volume (%TIV) | 14.2 [12.6, 14.8] | 13.3 [12.5, 14.1] | 13.8 [12.8, 14.6] | 0.36 |
| PiB SUVRs | 2.75 [2.43, 2.91] | 2.45 [2.19, 2.64] | 2.48 [2.23, 2.58] | 0.02‡ |
| Demographic features | ||||
| No. Female, n (%) | 8 (38%) | 12 (57%) | 13 (65%) | 0.22 |
| APOE e4 Carrier, n (%) | 16 (84%) | 10 (48%) | 14 (74%) | 0.049§ |
| Age at Tau, yrs | 76 [73, 80] | 64 [57, 73] | 62 [57, 68] | <0.001‡ |
| Age at onset, yrs | 70 [65, 74] | 60 [55, 65] | 55 [52, 62] | <0.001‡ |
| Disease duration, yrs | 5.58 [4.81, 9.09] | 4.00 [2.92, 5.08] | 4.05 [3.34, 6.86] | 0.04§ |
| Clinical features | ||||
| AD type, n (%) | <0.001¶ | |||
| Typical, n (%) | 17 (81%) | 6 (29%) | 16 (80%) | |
| Atypical, n (%) | 4 (19%) | 15 (71%) | 4 (20%) | |
| Atypical AD subtype, n (%) | 0.37 | |||
| Dysexecutive, n (%) | 0 (0%) | 5 (33%) | 2 (50%) | |
| Logopenic progressive aphasia, n (%) | 3 (75%) | 3 (20%) | 1 (25%) | |
| Posterior cortical atrophy, n (%) | 1 (25%) | 7 (47%) | 1 (25%) | |
| CDR-SB | 6.50 [4.25, 9.00] | 3.00 [2.00, 4.00] | 6.00 [2.00, 10.00] | 0.16 |
| Letter fluency (F) | 8.00 [6.00, 17.00] | 10.00 [7.00, 13.50] | 10.00 [8.50, 96.00] | 0.36 |
| Animal fluency | 9.00 [6.25, 15.50] | 9.50 [7.75, 14.00] | 14.00 [9.00, 96.00] | 0.08‖ |
| Trail Making Test A MOANS | 9.00 [8.25, 10.00] | 3.00 [2.00, 6.50] | 9.00 [5.75, 11.00] | 0.002¶ |
| Trail Making Test B MOANS | 7.00 [2.25, 8.00] | 2.00 [2.00, 3.00] | 7.00 [2.00, 9.00] | 0.31 |
| AVLT Delayed % Recall MOANS | 6.00 [4.00, 6.00] | 6.00 [4.00, 8.00] | 2.00 [2.00, 4.50] | 0.02* |
| Rey-O MOANS | 8.00 [7.00, 11.25] | 2.00 [2.00, 5.25] | 6.00 [3.00, 10.50] | 0.01§ |
APOE = apolipoprotein E; CDR-SB = Clinical Dementia Rating Scale Sum of Boxes; AVLT = Auditory Verbal Learning Test; Rey-O = Rey Osterrieth. MOANS = Mayo Older Adult Norms; TIV = total intracranial volume. MOANS scores are age corrected and constructed to have a mean of 10 and standard deviation of 3 among cognitively healthy subjects.
Data shown are n (%) or median [IQR]. P-values were assessed using Fisher’s Exact and Kruskal Wallis Rank Sum tests.
EHi/CHi is statistically different from ELo/CLo and ELo/CHi
All groups are statistically different from each other
ELo/CLo is statistically different from ELo/CHi and EHi/CHi
ELo/CLo is statistically different from ELo/CHi
ELo/CHi is statistically different from ELo/CLo and EHi/CHi
ELo/CHi is statistically different from EHi/CHi