Table 1.
Percent Mutational Frequency in Colon Cancer Genes
| Gene | % Mutated in Our AYA Samples (N=32) | % Mutated in Our Adult Samples (N=30) | % Mutated in COSMIC (N is Variable) | % Mutated in TCGA (N=224) |
|---|---|---|---|---|
| TP53 | 61 | 53 | 49 | 55 |
| APC | 74 | 73 | 42 | 72 |
| KRAS | 35 | 23 | 35 | 42 |
| ATM | 35 | 7 | 34 | 12 |
| PTEN | 26 | 3 | 28 | 4 |
| SMAD4 | 29 | 10 | 26 | 12 |
| PIK3CA | 45 | 20 | 22 | 15 |
| RB1 | 16 | 3 | 21 | 4 |
| FBXW7 | 39 | 10 | 20 | 18 |
| KIT | 26 | 3 | 20 | 5 |
| PTCH1 | 35 | 3 | 21 | 8 |
| NF1 | 29 | 3 | 20 | 4 |
| CREBBP | 29 | 13 | 19 | 10 |
| ARID1A | 29 | 20 | 17 | 11 |
| BRAF | 10 | 23 | 14 | 9 |
| KMT2D (MLL2) | 45 | 13 | 16 | 7 |
| CDH1 | 16 | 13 | 16 | 3 |
| TRRAP | 26 | 13 | 15 | 8 |
| MLH1 | 10 | 13 | 15 | 3 |
| CARD11 | 13 | 7 | 14 | 6 |
Comparison of the top twenty most frequently mutated genes in colon cancer according to the catalogue of somatic mutations in cancer (COSMIC) data base with the mutation frequency of our AYA and adult samples, and TCGA colon cancer samples.