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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Immunol. 2018 Jan 24;200(5):1580–1592. doi: 10.4049/jimmunol.1701280

Figure 2. IL-10 deficiency is protective in anti-B71/anti-B7-2-induced autoimmune peripheral polyneuropathy.

Figure 2

Anti-B7-1/anti-B7-2 or isotype treated WT or WT Il10−/− mice were monitored for SAPP. (A) SAPP incidence curves. p-value was calculated using Mantel-Cox log-rank test of anti-B7-1/anti-B7-2-treated WT Il10+/− versus WT Il10−/− mice; **, p < 0.01. Arrow points to age at which nerves were harvested for histology in B and C. (B) H&E-stained sciatic nerves from 12-week-old mice (magnification 200×). Arrows point to areas of dense immune cell infiltration. Scale bar = 60 μm. (C) Cumulative sciatic nerve infiltration scores from 12-week-old mice. p-value was calculated using Fisher’s Exact test; *, p < 0.05. Each symbol represents an individual mouse.