. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):50–56. doi: 10.1097/WAD.0000000000000215

Table 2.

Cross-sectional association between baseline MRI brain measures and presence of MCI (N=1049)

Baseline MRI Measure	Classification	MCI Outcome (versus no MCI)
		Any MCI (N=236)		Amnestic MCI (N=183)
		OR (95% CI)	P-value	OR (95% CI)	P-value
Total cerebral brain volume (%)	Continuous (Per SD increment)^a	1.04 (0.86–1.26)	0.68	1.13 (0.92–1.40)	0.24
Total cerebral brain volume (%)	Q1 vs Q234	1.07 (0.73–1.59)	0.72	0.83 (0.53–1.30)	0.41
Ln white matter hyperintensities volume (%)	Continuous (Per SD increment)^a	1.14 (0.97–1.35)	0.12	1.17 (0.97–1.42)	0.09
Ln white matter hyperintensities volume (%)	Q4 vs Q123	1.48 (1.03–2.12)	0.03	1.49 (0.99–2.23)	0.05
Hippocampal volume (%)	Continuous (Per SD increment)^a	0.79 (0.67–0.94)	0.007	0.72 (0.60–0.86)	0.0005
Hippocampal volume (%)	Q1 vs Q234	1.58 (1.12–2.24)	0.01	1.80 (1.23–2.64)	0.002
Covert brain infarct	Present vs Absent	1.46 (0.95–2.23)	0.08	1.55 (0.97–2.47)	0.06

All models are adjusted for age at MRI, sex, days between baseline MRI and baseline neuropsychological assessment, education group (<high school degree, high school degree, some college, ≥college degree), APOE ε4 status (carrier versus noncarrier) vascular risk factors (systolic blood pressure, hypertension treatment, diabetes, smoking, history of cardiovascular disease, history of atrial fibrillation), and all of the other MRI measures (continuous) listed in the table.

Standard deviation increment calculated using the entire sample.

Note that MRI variables expressed as percent are normalized by total intracranial volume to correct for head size.

Statistically significant findings (p < 0.05) appear in bold font.