Table 2.
Baseline MRI Measure | Classification | MCI Outcome (versus no MCI) | |||
---|---|---|---|---|---|
Any MCI (N=236) |
Amnestic MCI (N=183) |
||||
OR (95% CI) | P-value | OR (95% CI) | P-value | ||
Total cerebral brain volume (%) | Continuous (Per SD increment)a |
1.04 (0.86–1.26) | 0.68 | 1.13 (0.92–1.40) | 0.24 |
Q1 vs Q234 | 1.07 (0.73–1.59) | 0.72 | 0.83 (0.53–1.30) | 0.41 | |
Ln white matter hyperintensities volume (%) | Continuous (Per SD increment)a |
1.14 (0.97–1.35) | 0.12 | 1.17 (0.97–1.42) | 0.09 |
Q4 vs Q123 | 1.48 (1.03–2.12) | 0.03 | 1.49 (0.99–2.23) | 0.05 | |
Hippocampal volume (%) | Continuous (Per SD increment)a |
0.79 (0.67–0.94) | 0.007 | 0.72 (0.60–0.86) | 0.0005 |
Q1 vs Q234 | 1.58 (1.12–2.24) | 0.01 | 1.80 (1.23–2.64) | 0.002 | |
Covert brain infarct | Present vs Absent | 1.46 (0.95–2.23) | 0.08 | 1.55 (0.97–2.47) | 0.06 |
All models are adjusted for age at MRI, sex, days between baseline MRI and baseline neuropsychological assessment, education group (<high school degree, high school degree, some college, ≥college degree), APOE ε4 status (carrier versus noncarrier) vascular risk factors (systolic blood pressure, hypertension treatment, diabetes, smoking, history of cardiovascular disease, history of atrial fibrillation), and all of the other MRI measures (continuous) listed in the table.
Standard deviation increment calculated using the entire sample.
Note that MRI variables expressed as percent are normalized by total intracranial volume to correct for head size.
Statistically significant findings (p < 0.05) appear in bold font.