Table 1.
Patient characteristics in final cohort of patients
| Variables | No Chemo n (%) |
A-based n (%) |
A+T n (%) |
TC n (%) |
Other Taxane n (%) |
CMF n (%) |
p value | Total n (%) |
|---|---|---|---|---|---|---|---|---|
| All subjects | 71886 (78.0) | 3797 (4.1) | 8338 (9.1) | 3083 (3.4) | 2851 (3.1) | 2155 (2.3) | 92,110 | |
| Age group (y) | ||||||||
| Range | 65–114 | 65–90 | 65–93 | 65–91 | 65–99 | 65–94 | <0.001 | 65–114 |
| Mean | 76±7 | 71±5 | 70±4 | 71±5 | 73±6 | 73±6 | 75±7 | |
| Median | 76 | 69 | 69 | 70 | 73 | 73 | 74 | |
| 65 – 70 | 18228 (62.6) | 2170 (7.5) | 5081 (17.4) | 1613 (5.5) | 1246 (4.3) | 792 (2.7) | 29,130 | |
| 71 – 75 | 15704 (74) | 1038 (4.9) | 2221 (10.5) | 869 (4.1) | 762 (3.6) | 628 (3) | 21,222 | |
| 76 – 80 | 16246 (85.6) | 450 (2.4) | 860 (4.5) | 452 (2.4) | 496 (2.6) | 485 (2.6) | 18,989 | |
| >80 | 21708 (95.3) | 139 (0.6) | 176 (0.8) | 149 (0.7) | 347 (1.5) | 250 (1.1) | 22,769 | |
| Race | <0.001 | |||||||
| NH_White | 59826 (79.4) | 2923 (3.9) | 6345 (8.4) | 2421 (3.2) | 2163 (2.9) | 1661 (2.2) | 75,339 | |
| Hispanic | 4618 (69.8) | 346 (5.2) | 884 (13.4) | 251 (3.8) | 297 (4.5) | 225 (3.4) | 6,621 | |
| NH_Black | 4930 (71.5) | 371 (5.4) | 804 (11.7) | 300 (4.4) | 279 (4.1) | 207 (3) | 6,891 | |
| NH_Other | 2512 (77.1) | 157 (4.8) | 305 (9.4) | 111 (3.4) | 112 (3.4) | 62 (1.9) | 3,259 | |
| Year of diagnosis | <0.001 | |||||||
| 2003 | 10974 (79.9) | 952 (6.9) | 964 (7) | 31 (0.2) | 193 (1.4) | 615 (4.5) | 13,729 | |
| 2004 | 10706 (78.5) | 874 (6.4) | 1352 (9.9) | 45 (0.3) | 216 (1.6) | 451 (3.3) | 13,644 | |
| 2005 | 10328 (78.5) | 705 (5.4) | 1464 (11.1) | 53 (0.4) | 261 (2) | 351 (2.7) | 13,162 | |
| 2006 | 10125 (77.8) | 539 (4.1) | 1444 (11.1) | 284 (2.2) | 355 (2.7) | 272 (2.1) | 13,019 | |
| 2007 | 10040 (77.2) | 368 (2.8) | 1262 (9.7) | 641 (4.9) | 512 (3.9) | 185 (1.4) | 13,008 | |
| 2008 | 9851 (77) | 205 (1.6) | 981 (7.7) | 991 (7.7) | 613 (4.8) | 157 (1.2) | 12,798 | |
| 2009 | 9862 (77.4) | 154 (1.2) | 871 (6.8) | 1038 (8.1) | 701 (5.5) | 124 (1) | 12,750 | |
| Urban/Rural | <0.001 | |||||||
| Big Metro | 37980 (78.7) | 1818 (3.8) | 4232 (8.8) | 1662 (3.4) | 1499 (3.1) | 1084 (2.3) | 48,275 | |
| Metro | 21036 (78) | 1163 (4.3) | 2465 (9.1) | 842 (3.1) | 786 (2.9) | 677 (2.5) | 26,969 | |
| Urban | 4309 (76.5) | 291 (5.2) | 523 (9.3) | 190 (3.4) | 191 (3.4) | 132 (2.3) | 5,636 | |
| Less Urban | 6693 (76.8) | 411 (4.7) | 868 (10) | 272 (3.1) | 276 (3.2) | 201 (2.3) | 8,721 | |
| Rural/Unknown | 1868 (148.6) | 114 (8) | 250 (19.6) | 117 (11.7) | 99 (8) | 61 (4.2) | 2,509 | |
| Marriage status | <0.001 | |||||||
| Married | 27941 (74.2) | 1915 (5.1) | 4079 (10.8) | 1558 (4.1) | 1246 (3.3) | 941 (2.5) | 37,680 | |
| Not married | 36029 (82) | 1425 (3.2) | 3151 (7.2) | 1146 (2.6) | 1234 (2.8) | 932 (2.1) | 43,917 | |
| Unknown | 7916 (75.3) | 457 (4.4) | 1108 (10.5) | 379 (3.6) | 371 (3.5) | 282 (2.7) | 10,513 | |
| Education | <0.001 | |||||||
| 1st Quartile (highest) | 18348 (80.6) | 756 (3.3) | 1833 (8.1) | 789 (3.5) | 619 (2.7) | 432 (1.9) | 22,777 | |
| 2nd Quartile | 17998 (79.1) | 887 (3.9) | 1951 (8.6) | 772 (3.4) | 648 (2.9) | 500 (2.2) | 22,756 | |
| 3rd Quartile | 17593 (77.3) | 1044 (4.6) | 2129 (9.4) | 697 (3.1) | 717 (3.2) | 570 (2.5) | 22,750 | |
| 4th Quartile (lowest) | 17947 (75.3) | 1110 (4.7) | 2425 (10.2) | 825 (3.5) | 867 (3.6) | 653 (2.7) | 23,827 | |
| Poverty | <0.001 | |||||||
| 1st Quartile (lowest) | 18166 (79.6) | 810 (3.6) | 1957 (8.6) | 777 (3.4) | 638 (2.8) | 489 (2.1) | 22,837 | |
| 2nd Quartile | 17955 (78.9) | 911 (4) | 1965 (8.6) | 765 (3.4) | 650 (2.9) | 498 (2.2) | 22,744 | |
| 3rd Quartile | 17726 (77.9) | 990 (4.4) | 2029 (8.9) | 751 (3.3) | 749 (3.3) | 504 (2.2) | 22,749 | |
| 4th Quartile (highest) | 18039 (75.9) | 1086 (4.6) | 2387 (10) | 790 (3.3) | 814 (3.4) | 664 (2.8) | 23,780 | |
| Comorbidity | <0.001 | |||||||
| 0 | 43632 (78.2) | 2391 (4.3) | 5159 (9.2) | 1822 (3.3) | 1578 (2.8) | 1252 (2.2) | 55,834 | |
| 1 | 15311 (79.7) | 666 (3.5) | 1498 (7.8) | 609 (3.2) | 626 (3.3) | 494 (2.6) | 19,204 | |
| 2+ | 9165 (83.7) | 301 (2.8) | 579 (5.3) | 310 (2.8) | 359 (3.3) | 242 (2.2) | 10,956 | |
| Unknown | 3778 (61.8) | 439 (7.2) | 1102 (18) | 342 (5.6) | 288 (4.7) | 167 (2.7) | 6,116 | |
| Stage | <0.001 | |||||||
| Localized | 57156 (88) | 2075 (3.2) | 1782 (2.7) | 1551 (2.4) | 1269 (2) | 1110 (1.7) | 64,943 | |
| Regional | 14730 (54.2) | 1722 (6.3) | 6556 (24.1) | 1532 (5.6) | 1582 (5.8) | 1045 (3.9) | 27,167 | |
| Surgery | <0.001 | |||||||
| Breast conserving | 41922 (83.4) | 1821 (3.6) | 2921 (5.8) | 1526 (3) | 1079 (2.2) | 997 (2) | 50,266 | |
| Mastectomy | 25703 (70.7) | 1811 (5) | 4827 (13.3) | 1433 (3.9) | 1469 (4) | 1115 (3.1) | 36,358 | |
| No Surgery/Unknown | 4261 (77.7) | 165 (3) | 590 (10.8) | 124 (4.8) | 303 (10.9) | 43 (0.8) | 5,486 | |
| Radiation therapy | <0.001 | |||||||
| No | 35312 (83.5) | 1529 (3.6) | 2285 (5.4) | 1048 (2.5) | 1198 (2.8) | 945 (2.2) | 42,317 | |
| Yes | 36574 (73.5) | 2268 (4.6) | 6053 (12.2) | 2035 (4.1) | 1653 (3.3) | 1210 (2.4) | 49,793 | |
| Grade | <0.001 | |||||||
| Well Differentiated | 19516 (91.6) | 417 (2) | 658 (3.1) | 304 (1.4) | 155 (0.7) | 251 (1.2) | 21,301 | |
| Moderately Differentiated | 31232 (81.4) | 1447 (3.8) | 2838 (7.4) | 1197 (3.1) | 866 (2.3) | 800 (2.1) | 38,380 | |
| Poorly Differentiated | 15163 (60.5) | 1720 (6.9) | 4167 (16.6) | 1425 (5.7) | 1618 (6.5) | 955 (3.8) | 25,048 | |
| Unknown | 5975 (81) | 213 (2.9) | 675 (9.2) | 157 (2.1) | 212 (2.9) | 149 (2) | 7,381 | |