Figure 3.

In vivo ¹³C MRS measured in the healthy myocardium after the injection of a hyperpolarized UV-irradiated [1-¹³C]pyruvate/[1-¹³C]butyrate mixture. (A) Representative ¹³C spectral time course following the injection of the substrate mixture. Acquisitions were respiratory-gated and cardiac-triggered with a repetition time of 3 s and a flip angle of 30°. (B) Sum of the 15 spectra acquired starting 9 s after dissolution. The myocardial metabolism of both pyruvate and butyrate could be observed through the formation of alanine, lactate, bicarbonate and acetylcarnitine.