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(a) Preparation of bioreducible PECssD/siRNA micelles that are taken up by cells and the cleavage of disulfide bonds facilitates endosomal escape and siRNA release. (b) Mean fluorescence intensities of PECssD/Cy5-siRNA micelleplexes in isolated organs. (c) Inhibition of tumor growth in HeLa xenograft following i.v. injection of PECssD2/siPlk1. Reproduced with permission from[44]. Copyright 2013, Elsevier Ltd.
