Figure 1.

The proposed method is compatible with third-party TK solvers. Shown are results from an anatomically-realistic brain-tumor DCE-MRI digital reference object using an in-house solver and the Rocketship solver, both using the model consistency constraint method. R=60x were tested at white matter SNR level of 20 and 10. Tumor ROI K^trans nRMSE (normalized to 90%ile value) were shown on the upper left corner of respective K^trans maps. Correlation plots are shown at the bottom of each respective result, where the upper left corner shows the R² value, and lower right corner shows the correlation coefficient. Both methods were able to restore K^trans maps with less than 50% nRMSE, while the Rocketship solver yielded K^trans maps with higher errors, especially at SNR=10. K_ep and v_p maps are more sensitive to noise, especially when using the Rocketship solver.