Table 5.
Single-nucleotide polymorphisms that are associated with bone mineral density Z-score changes from diagnosis to week 120 and dexamethasone AUC
| SNP information
|
Association with bone mineral density Z-score change from diagnosis to week 120a
|
Association with dexamethasone AUC
|
|||||
|---|---|---|---|---|---|---|---|
| SNPID | Gene | Risk allele frequency | Risk allele | P | Coefficient | P | Spearman correlation |
| rs2622849 | COL11A1 | 0.051 | T | 2.39E-07 | −1.071 | 0.291 | 0.063 |
| rs11025915 | NELL1 | 0.025 | A | 4.07E-06 | −1.306 | 0.003 | 0.176 |
| rs1986582 | – | 0.120 | G | 7.17E-06 | −0.629 | 0.421 | 0.048 |
| rs17047225 | TLL1 | 0.050 | C | 7.51E-06 | −0.815 | 0.964 | 0.003 |
| rs2668354 | SRGAP3 | 0.659 | A | 1.00E-05 | −0.471 | 0.307 | 0.061 |
| rs7514670 | – | 0.849 | A | 1.14E-05 | −0.552 | 0.734 | −0.020 |
| rs12127272 | – | 0.320 | G | 1.23E-05 | −0.453 | 0.481 | 0.042 |
| rs9931454 | – | 0.787 | C | 2.11E-05 | −0.495 | 0.824 | 0.013 |
| rs11122844 | – | 0.192 | C | 2.22E-05 | −0.501 | 0.729 | 0.021 |
| rs3849317 | – | 0.723 | C | 3.01E-05 | −0.425 | 0.938 | −0.005 |
| rs1151982 | – | 0.017 | T | 3.07E-05 | −1.476 | 0.163 | 0.082 |
| rs4766635 | – | 0.641 | A | 3.10E-05 | −0.421 | 0.561 | 0.035 |
| rs885339 | – | 0.247 | T | 3.34E-05 | −0.418 | 0.259 | 0.068 |
| rs7957299 | PPTC7 | 0.657 | C | 3.69E-05 | −0.371 | 0.702 | 0.023 |
| rs17000495 | MUC16 | 0.801 | G | 4.02E-05 | −0.445 | 0.182 | 0.079 |
| rs41478351 | MGC45800 | 0.101 | C | 4.20E-05 | −0.665 | 0.545 | 0.036 |
| rs16931403 | NFIB | 0.173 | G | 4.22E-05 | −0.457 | 0.024 | 0.136 |
| rs9344006 | – | 0.122 | G | 4.31E-05 | −0.524 | 0.785 | −0.016 |
| rs4843860 | IRF8 | 0.763 | A | 4.47E-05 | −0.426 | 0.022 | 0.135 |
| rs9352839 | – | 0.118 | A | 4.69E-05 | −0.532 | 0.846 | 0.012 |
| rs41430546 | – | 0.070 | G | 4.73E-05 | −0.754 | 0.219 | 0.073 |
| rs3850825 | ZNF496 | 0.240 | G | 5.01E-05 | −0.416 | 0.884 | 0.009 |
| rs6817370 | – | 0.865 | T | 5.11E-05 | −0.557 | 0.092 | 0.099 |
| rs9522086 | – | 0.191 | A | 5.49E-05 | −0.442 | 0.062 | 0.110 |
| rs2664109 | SRGAP3 | 0.642 | A | 5.99E-05 | −0.402 | 0.265 | 0.066 |
| rs1940080 | DLG2 | 0.501 | A | 6.00E-05 | −0.376 | 0.717 | 0.021 |
| rs7738642 | – | 0.130 | T | 6.26E-05 | −0.497 | 0.530 | −0.037 |
| rs3863992 | – | 0.171 | A | 8.04E-05 | −0.478 | 0.328 | 0.058 |
| rs11165740 | – | 0.360 | T | 8.38E-05 | −0.379 | 0.187 | 0.078 |
| rs948640 | – | 0.812 | C | 8.40E-05 | −0.454 | 0.946 | −0.004 |
| rs7522071 | ZNF496 | 0.229 | T | 8.41E-05 | −0.411 | 0.627 | −0.029 |
| rs1588571 | LOC100129666 | 0.062 | A | 8.53E-05 | −0.776 | 0.002 | 0.181 |
| rs13179406 | RNF130 | 0.890 | A | 8.54E-05 | −0.536 | 0.754 | 0.019 |
| rs987341 | – | 0.062 | T | 8.60E-05 | −0.758 | 0.784 | 0.016 |
| rs4937993 | NCAM1 | 0.520 | T | 8.75E-05 | −0.370 | 0.013 | 0.146 |
| rs2297694 | C9orf72 | 0.275 | G | 9.05E-05 | −0.413 | 0.208 | 0.075 |
| rs17079966 | RNF130 | 0.865 | G | 9.22E-05 | −0.494 | 0.834 | −0.012 |
| rs16839677 | OLFML2B | 0.076 | A | 9.26E-05 | −0.692 | 0.683 | −0.024 |
Abbreviations: SNP ID, single-nucleotide polymorphism identifier according to the dbSNP database; AUC, area under the plasma drug concentration−time curve
a
Adjusted for age, genetic ancestry, treatment risk, and BMD Z-score at diagnosis.