Table 2. Ventricle-related ECG-derived predictors for new-onset AF.
†: From the pooled data of the Framingham study, the ARIC study3) and the Cardiovascular Health study40) for derivation and the Rotterdam study41) for validation in CHARGE-AF Consortium.25) BBB: bundle branch block or hemi-block. FU: follow-up. HR: hazard risk. LAFB: left anterior fascicular block. LBBB: left bundle branch block. LVH: left ventricular hypertrophy. NSVT: non-sustained ventricular tachycardia ≥3 beats. RBBB: right bundle branch block. PVC: ventricular premature contraction. Ref. No.: reference number. ST-T abn. : ST-T abnormality
| Author | Number of | FU | Annual | ECG finding | HR (95% CI, P-value) |
|---|---|---|---|---|---|
| (Ref No.) | participants | time | incidence | ||
| LVH | |||||
| Watanabe[51] | - | - | - | Sokolow-Lyon | 1.43 (1.13-1.80) |
| Perez[13] | - | - | - | Romhilt-Estes | 1.3 (1.0-1.7, P=0046) |
| Chrispin[75] | 4942 | - | - | Sokolow-Lyon | 1.83 (1.06-3.14) |
| Alonso[25] | - | - | - | - | 1.04 (0.99-1.10) to 2.96 (1.08-8.01) |
| Macfarlane[68] | 117 | - | - | Minnesota code, definite | 2.20 (1.44-3.37, 0.0003) |
| 138 | - | - | probable | 2.33 (1.58-3.44, <0.0001) | |
| 709 | - | - | possible | 1.35 (1.08-1.70, 0.010) | |
| PVC/runs | |||||
| Watanabe[51] | - | - | - | presence | 3.49 (2.40-5.08) |
| Perez[13] | - | - | - | presence | 1.5(1.2-1.9, P=0.004) |
| Agarwal[76] | 14,783 | 15-17yrs | - | presence in 2 min | 1.56 (1.30-1.87) |
| Lin[77] | 3751 | 10.1 yrs | 0.68 | multiform NSVT | 1.546 (1.058-2.258) |
| Lin[78] | 3367 | 10.1 yrs | 0.68 | NSVT (≥3 PVCs) | 1.546 (1.058-2.258) |
| 1.716(1.243-2.368) | |||||
| ST-T abn | |||||
| Watanabe[51] | - | - | - | without LVH | 1.89 (1.34-2.13) |
| Macfarlane[68] | - | - | - | Minnesota code 5-1/5-2 | 1.7 6(1.41-2.21, P<0.0001) |
| BBB | |||||
| Perez[13] | - | - | - | LBBB | 1.7(1.2-2.5, P<0.0001) |
| Watanabe[51] | - | - | - | LBBB | 0.96 (-) |
| RBBB | 0.84 (-)1.17(1.08-1.27, P<0.001) | ||||
| - | - | - | QRS width per 20 ms | 1.17(1.08-1.27, P<0.001) | |
| Macfarlane [68] | 4,696 | 12.3 yrs | 2.16% | LAFB | 2.1 (1.1- 3.9, P=0.023) |
| QTc | |||||
| Macfarlane[68] | - | - | - | per 30 ms increment | 1.31(1.20-1.42, P<0.0001) |
| Mandyam[83] | 14,538 | - | 0.51% | per 10 ms increment | 1.11(1.07-1.14, P<0.001) |
| ≥460ms (women)/≥450 ms (men) | 1.99 (1.37-2.89, P<0.001) | ||||
| Nielsen[84] | - | - | - | ≤372 ms | 1.45 (1.14-1.84; P=0.002) |
| ≥458 ms | 2.32 (1.52- 3.54, P<0.001) | ||||
| Nguyen[55] | - | - | - | ≥460 ms (women) or≥450 ms (men) | 2.5 (1.4-4.3, P=0.002) |