Table 1. Baseline Characteristics between Dofetilide and Sotalol groups (n = 378).
Characteristics | Dofetilide (n = 298) | Sotalol (n = 80) | p value |
---|---|---|---|
Demographics | |||
Age (years) | 64 ± 10.3 | 64 ± 11.6 | 0.46 |
Gender: Male (%) | 205 (68.8%) | 46 (57.5%) | 0.06 |
Race: Caucasian (%) | 270 (90.6%) | 71 (88.7%) | 0.14 |
Body Mass Index (BMI) | 33 ± 7.4 | 33 ± 7.8 | 0.90 |
Co morbidities | |||
Paroxysmal AF | 183 (61.4%) | 50 (62.5%) | 0.22 |
Hypertension | 252 (84.5%) | 67 (83.7%) | 1.00 |
Diabetes mellitus | 63 (21.1%) | 20 (25%) | 0.45 |
Hyperlipidemia | 218 (73.1%) | 66 (82.5%) | 0.08 |
Coronary artery disease | 93 (31.2%) | 41 (51.2%) | 0.001 |
Stroke/Transient ischemic attack | 25 (8.4%) | 10 (12.5%) | 0.10 |
Medication | |||
Beta Blockers | 89 (29.0%) | 28 (35.0%) | 0.57 |
Calcium Channel Blocker | 165 (55.5%) | 56 (70.0%) | 0.01 |
ACE Inhibitor/ARB | 89 (29.0%) | 28 (35.0%) | 0.57 |
Labs | |||
Creatinine Clearance (ml/min) | 105.2 ± 41.2 | 102.3 ± 37.4 | 0.58 |
Baseline Potassium level (mEq/L) | 4.12 ± 0.41 | 4.17 ± 0.36 | 0.90 |
Baseline Magnesium level (mEq/L) | 2.11 ± 1.1 | 2.0 ± 0.18 | 0.38 |
EKG/Echo | |||
Sinus rhythm on arrival | 83 (27.8%) | 32 (40%) | 0.03 |
Baseline QTc (msec) | 448.9 ± 33.2 | 444 ± 42.6 | 0.35 |
Left Atrial Size (cm) | 4.53 ± 0.8 | 5.45 ± 0.60 | 0.73 |
Left ventricle Ejection Fraction (%) | 51.7 ± 12 | 52.5 ± 12.6 | 0.65 |