Table 3. Safety outcomes between Dofetilide and Sotalol groups - Adverse events (n = 378).
Adverse events | Dofetilide (n = 298) | Sotalol (n = 80) | p value |
---|---|---|---|
Bradyarrhythmias | |||
Bradycardia (HR < 60) | 22 (7.4%) | 9 (11.3%) | 0.26 |
Sinus pause > 2 secs | 0 (0%) | 0 (0%) | - |
High grade AVB | 6 (2.0%) | 2 (2.5%) | 0.67 |
Ventricular arrhythmias | |||
New onset PVCs | 0 (0%)) | 0 (0%) | - |
Non Sustained VT | 7 (2.3%) | 1 (1.3%) | 1.00 |
Torsades de pointes (TdP) | 4 (1.3%) | 1 (1.2%) | 1.00 |
Ventricular fibrillation (VF) | 0 (0%) | 0 (0%) | - |
Drug Discontinuation | 24 (8.8%) | 4 (5%) | 0.47 |