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. 2018 Feb 20;116:149–158. doi: 10.1016/j.freeradbiomed.2018.01.004

Table 1.

Embryotoxicity of BaP and the effect of vitamin E in ICR mice.

Day	Dose	Litters	Embryos	Death	Resorption	Growth retardation	Cephalic NTDs	All NTDs	Other malformations
Day	mg kg^-1	n	n	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)
Blank control		18	226	1 (0.4)	8 (3.5)	7 (3.1)	3 (1.3)	6 (2.7)	2 (0.9)
E6.5	Corn oil	11	136	1 (0.7)	2 (1.5)	2 (1.5)	2 (1.5)	2 (1.5)	2 (1.5)
E6.5	200	11	136	18 (13.2)^a	30 (22.1)^a	32 (23.5)^a	8 (5.9)^a	11 (8.1)^a	78 (57.4)^a
E6.5	250	15	203	21 (10.4)^a	35 (17.2)^a	26 (12.8)^a	7 (3.4)^a	14 (6.9)^a	74 (36.5)^a
E6.5	300	12	163	31 (19.0)^a	49 (30.1)^a	61 (37.4)^a	14 (8.6)^a	18 (11.0)^a	78 (47.9)^a
E7	Corn oil	12	151	0	9 (6.0)	1 (0.7)	3 (2.0)	3 (2.0)	3 (2.0)
E7	250+VE	11	144	1 (0.7)	13 (9.0)	18 (12.5)	1 (0.7)	2 (1.4)	68 (47.2)
E7	250	24	331	16 (4.8)^b ^c	43 (13.0)^b	54 (16.3)^b	31 (9.4)^b ^c	44 (13.3)^b ^c	120 (36.3)^b
E7	300	14	177	9 (5.1)^b	23 (13.0)^b	26 (14.7)^b	12 (6.8)^b	15 (8.5)^b	79 (44.6)^b
E7	350	10	136	18 (13.2)^b	4 (2.9)	33 (24.3)^b	8 (5.9)^b	13 (9.6)^b	69 (50.7)^b

^a

P < 0.05, compared with E6.5 corn oil;

^b

P < 0.05, compared with E7 corn oil;

^c

P < 0.05, compared with E7 250+VE. VE, vitamin E.