Table 1.

Emerging themes describing patient attitudes towards a future predictive radiogenomics test for breast radiation toxicity

Main theme	Sub-themes (description)
1. Willingness to undergo a radiogenomics test	•Additional information is good but may lead to information overload. •HCPs as the trusted expert should receive and explain test result and provide patient with a management plan accordingly.
2. Implications of a radiogenomics test	•Preparation and planning both for patient and HCPs. •Enhances anxiety or dread, particularly in the absence of symptom modifiers, or if long-term toxicity, such as scarring and chronic pain, was predicted.
3. Impact on treatment decision-making	•Benefit of cancer cure is prioritised over risk of treatment side-effects, particularly acute toxicity, which is usually transient. •Preserving breast integrity is more important than avoiding acute side-effects by undergoing more surgery (e.g. mastectomy ± reconstruction). •Individual preferences may dictate whether patients change their treatment plain to avoid radiotherapy in case of significant predicted long-term side-effects.

HCP, healthcare professional.