Fig. 3.

UE2316 levels in (A) plasma and (B) liver and brain in mice measured following a single oral dose. Drug levels reached a peak at 2 h post-dose (HPD) at all sites and were declining by the 4 h time point. (C) Amounts of UE2316 were quantified relative to the matrix cluster ion m/z 417.04834 Da by mass spectrometry imaging. The highest levels were found in hippocampus and all regions showed peak amounts at 2 h post-dose. Drug was not detected (ND) in brain regions of untreated animals. Statistical analysis was performed using a one-way ANOVA with Bonferroni's post hoc test. Data are mean ± SEM (n = 3). ^**p < 0.01 and ^*p < 0.05.