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. 2018 Feb 21;8:3398. doi: 10.1038/s41598-018-21768-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo efficacy of DpdtC in the SK-OV-3 xenograft tumor model. (A) Mean tumor volumes of mice xenografted with SK-OV-3 cells and treated with DpdtC (5 mg/kg). There were 6 animals per treatment group. DpdtC treatment started as indicated in the graphs (black arrows). Error bars show ± SD. (***P < 0.001). (B) On day 24, xenograft tumor from each group were removed and photographed. Representative tumors in each group were shown. (C) Effect of DpdtC on nude mice body weight was determined using SK-OV-3 tumor-bearing nude mice. Mice were weighed at regular intervals during the whole period to monitor therapy-related toxicity. (D) Histological examination was conducted in nude mice post injection with DpdtC (5 mg/kg) for two times. Images (magnification, ×400) of liver from nude mice (n = 3) injected with PBS (−) or DpdtC (5 mg/kg) for two times were obtained by staining with hematoxylin and eosin. Scale bars, 50 μm.