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. 2018 Feb 21;8:3443. doi: 10.1038/s41598-018-21652-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tubulation repair of the sciatic nerve gap exhibited comparable muscle re-innervation to nerve autografting 6 months post-injury. (A) Representative traces of compound muscle action potentials (CMAP) recorded in tibialis cranialis when stimulating the proximal sciatic nerve. The insert shows the scale bar for all traces. (B,C) Bar charts showing recovery index of CMAP amplitude in tibialis cranialis and gastrocnemius muscles, respectively. Recovery index was calculated as a ratio of peak CMAP amplitude on the injured side over that on the contralateral normal side. The 3-mm conduit group showed significantly improved recovery index compared to nerve autograft group. (D,E) Wet weight ratio of tibialis cranialis and gastrocnemius muscles, respectively. Data are expressed as mean±SEM (n = 10 rats each).