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. 2018 Feb 21;8:3430. doi: 10.1038/s41598-018-21653-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Carbohydrate metabolic pathway components differentially expressed in response to increasing oxidative stress. Enzymes found to be differentially expressed in the glycolysis/gluconeogenesis (blue), pentose phosphate (red), fermentation (yellow), and tricarboxylic acid (TCA) cycle (green) pathways are plotted based on their associations found in the KEGG database. Larger fonts correspond to compounds in the pathways while smaller, italicized fonts represent enzymes. The 2 × 3 heatmaps represent each isolate and fold change in expression observed relative to the control for each H₂O₂ treatment. Red and blue colors represent significantly higher and lower expression, respectively; white color represents no significant change in expression; and gray color represents treatments not measured in this experiment. Abbreviations: G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6 P, fructose-1,6-bisphosphate; Gly3P, glyceraldehyde-3-phosphate; Gly1,3PP, glyceraldehyde-1,3-bisphosphate; PEP, phosphoenolpyruvate; 6PGLac, 6-phosphogluconolactone; 6PGlu, 6-phosphogluconate; Ribu5P, ribulose-5-phosphate; Rib5P, ribose-5-phosphate.