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. 2018 Feb 21;9:588. doi: 10.1038/s41467-018-03126-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Longitudinal changes in brain structure across adolescence (ages 8–30). a Consistent patterns of change across four independent longitudinal samples (391 participants, 852 scans), with increases in cerebral white matter volume and decreases in cortical grey matter volume (adapted from Mills et al., 2016, NeuroImage¹⁰⁵). b Of the two main components of cortical volume, surface area and thickness, thinning across ages 8 to 25 years is the main contributor to volume reduction across adolescence, here displayed in the Braintime sample (209 participants, 418 scans). Displayed are regional differences in annual percentage change (APC) across the whole brain, the more the color changes in the direction of green to blue, the larger the annual decrease in volume (adapted from Tamnes et al., 2017, J Neuroscience¹⁵)