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. 2018 Feb 21;9:588. doi: 10.1038/s41467-018-03126-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Longitudinal neural developmental pattern of reward activity in adolescence. Longitudinal two-wave neural developmental pattern of nucleus accumbens activation during winning vs. losing, based on 249, and 238 participants who were included on the first and second time point, respectively (leading to 487 included brain scans in total). A quadratic pattern of brain activity was observed in the nucleus accumbens for the contrast winning > losing money in a gambling task, with highest reward activity in mid-adolescence. (Adapted with permission from Braams et al.⁵⁵)