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. 2018 Feb 21;8:3377. doi: 10.1038/s41598-017-17540-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lysosomal inhibition increases medial calcification. Mouse thoracic aortas were isolated from C57BL/6 J mice and cut into 3 mm-long aortic rings. Aorta segments were cultured in calcification media (DMEM + 10% FBS + 2.6 mM Pi) with or without chloroquine for 8 days. (A) HE and Von Kossa staining showing chloroquine effect on Pi-induced medial calcification. (B) Calcium assay showing effect of chlorquine on Pi-induced calcium accumulation. The data represent 6 aortic rings per each group. Values are presented as mean ± SEM. *P < 0.05.