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. 2018 Feb 21;8:3381. doi: 10.1038/s41598-018-21714-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Calibration plot with R². (a) Calibration plot of the imputed development dataset (n = 1,649). (b) Calibration plot of the external dataset also imputed (n = 595). Internal and external samples used for validation were divided in 10 deciles, according to their predicted risk. For each decile, the mean predicted risk and the mean observed cases are shown on the X and Y axes, respectively. Bars indicate 95% Poisson confidence intervals.